Staying downtown is by far the best location. Close to a lot of the sights to see, and very walkable. No need for a rental car at all, and public transit is good for longer distances, or if it is pouring rain!
Vancouver has a pretty small downtown area. You can see that on the map below. The downtown area is very walkable and public transit is good. Stay in the following area. Waterfront to the North, Stanely Park, Westend to the West, Yaletown to the Southeast, Granville Bridge to the South. Do not stay East of Cambie Street, at that point you are getting into the "not so nice" area of downtown.
Those condos above and around Rogers and Costco are east of Cambie, totally fine and likely to appear on VRBO or Airbnb. Certainly some of what's east of Cambie is scuzzy but not all. Use Google Street View and Youtube before finalizing.
That map of Downtown does not include the West End, which is a huge omission, IMO. Some of the best accommodation for a visitor is in the West End.
How many nights are you planning?
How are you planning on getting to Seattle? A day trip will take 10+ hours, more if you try to do it by train.
Temperatures hover between -2C and 5C at that time of year.
Hmmm, I can see the WE in the google link I gave, but if that's not good enough, perhaps this will do the trick
It's only that the part that is shaded in red for "Downtown" does not include the West End. Are you on a phone? The western boundary for the red area is Burrard, south to the edge of False Creek and north to Canada Place. East to mostly Carrall St but extends to Main St in front of PC Station. The WE is there, but not part of the red section. If you Google map West End, it shows up in red by itself.
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