We just stayed there. 2 block walk to Waterfront Station. Get a Compass Pass. Very useful. Waterfront station is always busy.
Yaletown Roundhouse to the ferry to Granville Island
You can also take the #50 False Creek South bus in front of Waterfront Station to the Island also.
I love using the little ferry to get to Granville Island! You can get some nice views when you are crossing over as well. Have your camera ready! Cash only though.
20 minute walk, but if you take Canada Line (2 stops) and choose to forego a Compass Card, you can tap a Visa/Mastercard.
No one has mentioned that the two ferry systems that ply False Creek are both private companies so you will need to pay their fares separately from any Compass Card or pass or ticket you have purchased for the transit system.
Thank you traveller47 and Vancouverite. I mentioned cash only, but should have given more information.
Wonderful thank you all!
Re: Aquabus. I take it regularly to Granville Island. At that stop (only) there is a credit card machine for arriving and departing passengers' use. On a fine weather day, it's worth purchasing a "day pass" for the Aquabus, and taking the mini cruise around False Creek, exploring at the various stops.
The least costly, least complicated way to get from the hotel to Granville Island will be to take the #50 bus from Waterfront Station right to Granville Island. Tap on with your touchless credit card, or coin fare ($2.95 for adults, $1.90 for seniors/youth with ID; driver will not be fussed if you round up to the next dollar). No change is given on the bus.