Get a road map at www.guiaroji.com.mx the best $25 bucks or so you will ever spend. Shows all roads currently including toll ones with the costs of tolls, location of Gas stations & tool booths.
Basically highway 2 to highway 15 (mostly toll) all the way to Guadalajara, but get the map for lots of other information, including city maps, distances between cites & the other info I mentioned earlier. Or you may also choose to cross at Nogales taking Highway 15 all the way. & is only 1694 Kilometers or about 1,050 miles in Mexico.
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